Rising Tide Biology is founded by Kevin Curran.
Kevin Curran received his B.S. in Biology from Southern Oregon University and his PhD in Molecular Biology from the University of Washington in Seattle.
Previous work…
- cancer research at Memorial Sloan Kettering Cancer Center
- stem cell research at UC San Francisco (human embryonic stem cell therapies for heart tissue)
- behavioral neuroscience at the Salk Institute (effect of serotonin on fear and anxiety)
Kevin now serves as a consultant and delivers educational seminars for the biotech/pharma community.
If interested in collaborating, please reach out with this contact form.
Here I am explaining human genetic modification to an industry audience.
Select Publications
Stem cell related papers:
Cooper, C.D., Erickson, S.D., Yin, S., Moravec, T., Peh, B., Curran, K. (2018) Protein Kinase A Signaling Inhibits Iridophore Differentiation in Zebrafish. Journal of developmental biology. 6(4). [link to paper]
Curran K, Prendergrast A, Parichy,D.M., Kunkel, G, Lister J.A., Raible D.W. 2010. Interplay between Foxd3 and Mitf regulate cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344, 107-118. [link to paper]
Curran K, Raible D.W., Lister J.A. 2009. Foxd3 controls specification of pigment cell types in the zebrafish neural crest by regulation of Mitf. Developmental Biology.332, 408-417. [link to paper]
Drug discovery papers:
Liu, Zheng, Maro J. Kariya, Christopher D. Chute, Amy K. Pribadi, Sarah G. Leinwand, Ada Tong, Kevin P. Curran et al. “Predator-secreted sulfolipids induce defensive responses in C. elegans.” Nature communications 9, no. 1 (2018): 1128. [link to paper].
Curran K and Chalasani SH. 2012. Serotonin circuits and anxiety: what can invertebrates teach us? Invertebrate Neuroscience. 12, 81-92 [link to paper]
Select images
Figure. 1 Neurobiology of mammalian fear/anxiety response – from Serotonin circuits and anxiety: what can invertebrates teach us? (Curran, 2012) Salk Institute for Biological Studies.
a. Threatening stimulus approaches the subject.
b. Physiological processing of threatening stimulus. Distressing visual information enters the retina, is processed by visual circuitry, and activates the hypothalamus. Once engaged, the hypothalamus initiates the HPA axis.
c. Enlarged view of neurological processing of threatening stimulus. Amygdala processing (purple arrows): Visual data captured by the retina is first processed by the thalamus, which in turn innervates the amygdala (green regions). The amygdala integrates memory information from the hippocampus and context and autonoetic consciousness from the cortex. Serotonergic circuit (red arrows): Serotonin is released from pre-synaptic neurons within the dorsal and median raphe nuclei on the midline of the brainstem. Serotonergic neurons innervate regions of the cerebellum, thalamus, hippocampus, hypothalamus, basal ganglia, frontal cortex, and amygdala.
Image credit: Science, 1999
Figure. 1: Fungus and oak tree root image with S.E.M. (Curran, Southern Oregon University) from Biocomplexity Blooms in NSF’s Research Garden [link to article]